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Mystery Solved

I went in for bloodwork and ultrasound (again) this morning before the crack of dawn (no kidding… the sun wasn't up when I arrived at the office), and the mystery is solved. My hormone levels had sort of leveled out and weren't where they expected them to be given a 16mm follicle on Friday. This explains bringing me back for more monitoring today instead of triggering last night.

Now I have 2 follicles on the Right: 13.6mm and 14.6mm instead of one 16mm follicle. How could this be? The sonographer thinks that there were probably two follicles developing so close together that the septum was difficult to visualize. And, she said, the bonus is that I now have two good looking follicles, which is great.

So that's where I am.

More Info

I'm just Posty McPostyson today!

Just got a call from Shady Hell. My estradiol is 118 (this is not amusing me, since last Wednesday it was 103, and had apparently gone down a little bit on Friday, though I don't know Friday's number).

My estrogen NEVER gets as high as the nurses seem to think it should, but I've asked my doctor about it before and she said it's not surprising in PCOS patients, and that she really doesn't care as much about the raw number as she does about the comparative levels from visit to visit. My preliminary web research suggests that my doctor was being diplomatic, as it appears to be specifically excess weight that can result in lower estradiol numbers (which is weird, since fat cells produce estrogen, so you'd think it would be elevated, but I suppose there are different kinds of estrogen, so maybe that's why).

My LH is 1.6 which doesn't make any sense to me. Everything I've found suggested that the LH surge should show >20 mIU/ml, so I'm thinking they're using a different scale (so maybe this is really a 16 on that scale?). I also find this completely unamusing. But I'll just sit, smile, and nod and do anything they tell me.

In this case, anything they tell me includes going in tomorrow instead of Tuesday (as I'd originally been told). Since I'm making the appointment at the last possible second, the only appointment they have for me is 8:15, a full hour than I usually like to be there. I much prefer the 6:45 or 7am appointment, but 7:15 is usually my last resort. 8:15 is all manner of inconvenient, but at least I'm still working fairly close to the Rockville office. I'll likely be changing jobs at the end of the month and THEN it will be much harder to manage with an 8:15 appointment.

Odd…

Weird. I’m told to increase my dosage by 18 IUs tonight and tomorrow and return for monitoring Sunday. How weird is that? I’m not sure what to make of it, but I couldn’t get any more specifics because my nurse called while J was throwing a bit of a hissy fit. So I didn’t hear any useful information, but I can only assume my estradiol or LH wasn’t where they wanted it to be yet.

CD10

I had bloodwork drawn and an ultrasound done this morning. My beautiful 14.7mm follicle is now 16mm. Lining is 8.9. Doctor wanted one more day and then have me back tomorrow to check before probably triggering tomorrow night.

Except I can’t come in on Saturdays, which the tech remembered and pointed out. I wasn’t planning to say anything about not coming in on Saturday, I figured I’d work it out with my nurse when she called with my E2 and LH levels and instructions.

If I absolutely had to have an IUI (or in the case of IVF: retrieval or transfer) on a Saturday, I’d do it. There’s a hotel within walking distance, and the clinic knows how to handle patients who have to come in on Friday to show ID and sign paperwork if necessary. But for a monitoring appointment, my Rav, while willing to say I *could* go if there were no way around it, doesn’t love the idea (and neither do I. It’s a lot of trouble for not a lot of gain). This is my fifth IUI cycle. My body is pretty predictable.

Fortunately, the doctor agrees that it’s not entirely necessary (though possibly preferable). After he gets a look at the E2/LH levels, he’ll confirm, but his suspicion is that we’ll give that beauty of a follicle another day to ripen before it hatches so that it’s around 18mm when it’s released. So that means no more monitoring appointments, but a trigger tomorrow night and an IUI Monday.

I would have preferred a Sunday IUI, but I can live with Monday. Can’t be too picky, after all. Plus with my mother out of town, I don’t know what we’d do with J if my husband and I both needed to be at Shady Hell on Sunday (though I suppose he could go and come back and then I could go, but I’d be cutting it really close for my appointment if we did that)

This is the fastest cycle on record for me. Triggering on Day 11, if that’s what happens, is unprecedented. My previous IUI was on Day 16, which was already super-early for me (but it worked, so I’m not complaining). I’m all for this cycle being over, though… the discomfort on my right side has turned into quite considerable pain. Not debilitating, obviously, but enough to make me want it to go away.

Odd…

Weird. I'm told to increase my dosage by 18 IUs tonight and tomorrow and return for monitoring Sunday. How weird is that? I'm not sure what to make of it, but I couldn't get any more specifics because my nurse called while J was throwing a bit of a hissy fit. So I didn't hear any useful information, but I can only assume my estradiol or LH wasn't where they wanted it to be yet.

CD10

I had bloodwork drawn and an ultrasound done this morning. My beautiful 14.7mm follicle is now 16mm. Lining is 8.9. Doctor wanted one more day and then have me back tomorrow to check before probably triggering tomorrow night.

Except I can't come in on Saturdays, which the tech remembered and pointed out. I wasn't planning to say anything about not coming in on Saturday, I figured I'd work it out with my nurse when she called with my E2 and LH levels and instructions.

If I absolutely had to have an IUI (or in the case of IVF: retrieval or transfer) on a Saturday, I'd do it. There's a hotel within walking distance, and the clinic knows how to handle patients who have to come in on Friday to show ID and sign paperwork if necessary. But for a monitoring appointment, my Rav, while willing to say I *could* go if there were no way around it, doesn't love the idea (and neither do I. It's a lot of trouble for not a lot of gain). This is my fifth IUI cycle. My body is pretty predictable.

Fortunately, the doctor agrees that it's not entirely necessary (though possibly preferable). After he gets a look at the E2/LH levels, he'll confirm, but his suspicion is that we'll give that beauty of a follicle another day to ripen before it hatches so that it's around 18mm when it's released. So that means no more monitoring appointments, but a trigger tomorrow night and an IUI Monday.

I would have preferred a Sunday IUI, but I can live with Monday. Can't be too picky, after all. Plus with my mother out of town, I don't know what we'd do with J if my husband and I both needed to be at Shady Hell on Sunday (though I suppose he could go and come back and then I could go, but I'd be cutting it really close for my appointment if we did that)

This is the fastest cycle on record for me. Triggering on Day 11, if that's what happens, is unprecedented. My previous IUI was on Day 16, which was already super-early for me (but it worked, so I'm not complaining). I'm all for this cycle being over, though… the discomfort on my right side has turned into quite considerable pain. Not debilitating, obviously, but enough to make me want it to go away.

CD 8

5 days of Follistim under my belt, and it was back to Shady Hell to see what was going on. Here are the basics:

Right Ovary: 1 follicle measuring 14.9mm; 7 follicles under 10mm.
Left Ovary: 1 follicle measuring 11.7mm and on measuring 10.3mm; 6 follicles under 10mm.
Endometrium: 8.7mm (is that good? they seemed all excited about it)
E2: 103 (again with, is that good?)

Two more days of Follistim at the same dose, and back on Friday. I have this feeling that I’m going to end up triggering on Friday (CD10) and having an IUI on Sunday. That’s the fastest cycle on record (for me). Shocking.

Oddly enough, I’m having some pretty noticeable pain on my right side, enough that I notice it and I’ve got a pretty high pain tolerance. It’s not debilitating or anything, but it’s definitely distracting.

Also, I realized tonight that I’ve been taking the wrong dose. I was supposed to take 66IUs per night, but I accidentally have been going one more click on the pen than I should and have been taking 75IUs each night. Obviously nothing horrible has happened as a result, and it’s not a big difference, but I feel a little sneaky. Except, well, I wasn’t being sneaky, I was being careless. Well, anyway, I’m not going to revert to 66 (particularly since it’s working and I didn’t have some scary alarming response that made everybody worry), but I imagine I ought to mention it to my nurse anyway. Sigh.

CD 8

5 days of Follistim under my belt, and it was back to Shady Hell to see what was going on. Here are the basics:

Right Ovary: 1 follicle measuring 14.9mm; 7 follicles under 10mm.
Left Ovary: 1 follicle measuring 11.7mm and on measuring 10.3mm; 6 follicles under 10mm.
Endometrium: 8.7mm (is that good? they seemed all excited about it)
E2: 103 (again with, is that good?)

Two more days of Follistim at the same dose, and back on Friday. I have this feeling that I'm going to end up triggering on Friday (CD10) and having an IUI on Sunday. That's the fastest cycle on record (for me). Shocking.

Oddly enough, I'm having some pretty noticeable pain on my right side, enough that I notice it and I've got a pretty high pain tolerance. It's not debilitating or anything, but it's definitely distracting.

Also, I realized tonight that I've been taking the wrong dose. I was supposed to take 66IUs per night, but I accidentally have been going one more click on the pen than I should and have been taking 75IUs each night. Obviously nothing horrible has happened as a result, and it's not a big difference, but I feel a little sneaky. Except, well, I wasn't being sneaky, I was being careless. Well, anyway, I'm not going to revert to 66 (particularly since it's working and I didn't have some scary alarming response that made everybody worry), but I imagine I ought to mention it to my nurse anyway. Sigh.

CD 8

5 days of Follistim under my belt, and it was back to Shady Hell to see what was going on. Here are the basics:

Right Ovary: 1 follicle measuring 14.9mm; 7 follicles under 10mm.
Left Ovary: 1 follicle measuring 11.7mm and on measuring 10.3mm; 6 follicles under 10mm.
Endometrium: 8.7mm (is that good? they seemed all excited about it)
E2: 103 (again with, is that good?)

Two more days of Follistim at the same dose, and back on Friday. I have this feeling that I'm going to end up triggering on Friday (CD10) and having an IUI on Sunday. That's the fastest cycle on record (for me). Shocking.

Oddly enough, I'm having some pretty noticeable pain on my right side, enough that I notice it and I've got a pretty high pain tolerance. It's not debilitating or anything, but it's definitely distracting.

Also, I realized tonight that I've been taking the wrong dose. I was supposed to take 66IUs per night, but I accidentally have been going one more click on the pen than I should and have been taking 75IUs each night. Obviously nothing horrible has happened as a result, and it's not a big difference, but I feel a little sneaky. Except, well, I wasn't being sneaky, I was being careless. Well, anyway, I'm not going to revert to 66 (particularly since it's working and I didn't have some scary alarming response that made everybody worry), but I imagine I ought to mention it to my nurse anyway. Sigh.

CD Whatever

So, here’s the thing. Wednesday could easily have been described as “full flow” making it CD 1. And then most of yesteday? Almost nothing. Today? Full flow is definitely a good description.

So is this CD1 or 3 or whatever?

Well, whatever it is, I went in for CD3 monitoring this morning. They managed to draw my blood in just one try today, which is nothing short of miraculous since Dracula had the day off. And I got to see my beloved Margaret, the super sonographer. My one bright spot in this whole ridiculous ordeal of having to do this all over again is that I get to see Margaret again. M is responsible for my blog name, you know. She always refers to my ovaries as “perky” because they’re always full of antral follicles, which, yes, I get is a good thing, but it was, for a time, disconcerting to hear my ovaries referred to as perky. They felt slightly mocked at first, you see, which is (I’m certain) why the first IUI didn’t work (though it doesn’t explain why the 2nd and 3rd didn’t work… surely by then they were used to the good-natured ribbing?).

MY POINT… if I ever had one in the first place, is that I adore Margaret. So while I wasn’t entirely PLANNING to see her again until April or so of 2008, I’m happy to see her now, even if it’s because my body sucks.

Anyway, today was no terrible shock. My ovaries, true to form, are definitely perky. I couldn’t count the number of antral follicles even in one single view, let alone by seeing it all the way through. So I think it’s safe to say that I’ve got good ovarian reserve. Shocker. Also that if I were to do IVF I’d be a super responder. Another shocker. But it does rather accentuate why it is that IUI is such a dragged on process for me. With that many eager follicles, they’ve got to be careful to bring just one or two to the front and ditch the rest. So teeney, teeeney, teeeeney doses of follistim for me. (More than last time, though, 66IUs) Assuming, of course, that my E2, P4, and Beta all come out indicating that it’s appropriate to start stims. And they had BETTER come out saying so, because I just spent scads of money on Follistim. Which brings me to the one surprise of the morning:

I stopped at the pharmacy on my way out to pick up my Follistim. I’m fairly certain that I have a vial at home, but I’d hate to get home and find out it was no good or had been misplaced, or had expired, or whatever after I got home. Shabbos comes in at 4:30 today, so there wouldn’t have been time to find a more local pharmacy to take care of it. So I stopped to pick up a vial just in case. Anyway, my insurance had rejected the Follistim because it didn’t “match the existing authorization.” My insurance has paid for probably 30 vials of Follistim in the last year, but I think the problem is that there was an intervening order for Gonal-F back in November, which I decided against using, because it’s such a pain in the neck for non-standard dosing.

I’m certain the insurance will pay for it once it’s resubmitted, but in the meantime I had to pay out of pocket for it. Not the end of the world, fortunately, but not inexpensive. Since I’m taking such a tiny dose, one vial should get me through about 5 days, possibly 6. And that one vial cost me $300. I know people who take 5 vials PER DAY for IVF cycles (I’d never be allowed to take that much for fear of OHSS). That’s $1500 PER DAY. If they take stims for the standard 12 days, that $18,000 in drug costs alone for an IVF cycle. Actually, that’s $18K for JUST ONE of the many necessary medications. Holy Schmoly! Suffice it to say, I’m thrilled that I have generally good health insurance and that it covers the medications as well, despite this temporary hiccup.

(I do know that the pharmacy I use heavily discounts their Follistim for out-of-pocket IVF patients. They didn’t discount it for me, because they know that the insurance WILL cover it in the long run and because it was “only” one $300 vial. So at least I know they give a lot of folks a bit of a break, but even so, I can’t imagine how devastating the costs must be for someone with no insurance coverage in need of that high a dose of stims! Ugh!)

So, um, let the fun begin!