Archive for February 10th, 2009

A Fair Question

Anonymous asks, re: my post about PIO counteracting my Allegra…

Could you actually be allergic to the PIO?

I could be, sure. But it’s unlikely. I’m not displaying symptoms in a way that would suggest that. First, my allergies are at their worst when I’m in my house. Around my cats. Coincidence? I think not! Second, if I had an allergy to the PIO, it is unlikely that it would come across with symptoms similar to seasonal and cat allergies.

More likely, I’d be reacting to the sesame oil. But, though I don’t care for sesame a great deal, I’ve never had a reaction to sesame in anything. But if I were to have a reaction to the sesame, I’d probably have an on-site reaction at the injection-site first. It would be itchy, possibly red and swollen. If it were a terrribly bad reaction, I imagine I could even have a systemic, anaphylactic reaction. But – thank heavens, I am not allergic to sesame.

As for the progesterone … according to the all-mighty pharmacist in my household, the progesterone in the PIO is derived from potatoes. Or yams or something. I don’t know, I’d like to say I was hanging on his every word, but something about it’s easier to derive from a plant substance than to weasel it out of a human being or whatever. So, unlikely that I’m having an allergic reaction to that either, unless there was some kind of impurity in it from the manufacturing process, but that’s unlikely, and again – the symptoms I’m having are unlikely to be the result of this kind of allergy.

Now, there is some evidence of estrogen and progesterone allergies, but those are with naturally occurring estrogen and progesterone – and those “allergies” are linked with menstrual-cycle-related asthma and migraines. Neither of which I have (I do have migraines, but mine have no relationship to my menstrual cycle whatsoever).

Dr. Beer suggests that there is evidence of a progesterone allergy, stating: Some autoimmune women develop allergies to their own hormones, including progesterone. The antibody which they have produced can be detected by looking for progesterone antibodies in the blood or by doing a skin test that shows the allergy to progesterone. These antibodies further decrease the levels of progesterone in the blood. The cells responsible for this are the CD 19+5+ cells. By 10 weeks of pregnancy these cells are usually suppressed to normal numbers and the progesterone allergy is less of a problem.

But, again, there’s no suggestion that this should, say, make me sneeze.

Truthfully, it could just all be coincidental. But I think there *might* be a relationship. When I was pregnant, my Allegra all-out stopped working and I was miserable for months until *boom* it started working again. And I know that “they” say when you’re pregnant, allergies are often exacerbated. So I suspect that there is *some* correlation between the worsening of my allergy symptoms and the high levels of progesterone in my system right now. My guess is that the Allegra just isn’t able to counterbalance it right now.

That’s my theory anyway. And we all know my theory is worth exactly what you paid for it.

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I found an excuse to bug my nurse for the cryo report. For the sake of shalom bayis I must know the disposition of those struggling little blastocysts! Honest! For those of you who don’t want to click on the link, shalom bayis is literally “peace in the home” – it is the concept of peace and harmony in the household and good relations between husband and wife. In this case, I realized that if there was anything to freeze (again, I think not), then I’m likely to get nailed with ~$1500 bill for freezing and storage (it’s a little less, but just go with me, okay? And actually, it it was just one, it’s significantly less). A girl’s gotta prepare her husband for a bill like that, right?

So, for the sake of domestic tranquility, I emailed SuperNurse and said, you know, I hate to be nosy and all, but does she know the disposition of my struggling little life forms? And really, she wouldn’t want our marriage to be in jeopardy, right? It’s for the sake of our marriage! Plus, after all, enquiring minds want to know! This is front page news! Sort of.

Okay, not remotely, but I’m sure all of you are clamoring to know. Right? RIGHT?

Ahem. All righty then. So it’s just ME that wants to know. Yet another way for me to pass the time. The endless, boring time stretched before me. Another eight, looooooooong days before my beta. With nothing to do but sit here and whine, complain, bitch, blither to you about the mundanity of life when there is absolutely nothing interesting going on in my life. Absolutely nothing worth blogging about.

Nothing to see here, move along. Move along.

Oh! Hey! If there was *nothing* to freeze, maybe I can convince the man that since he just saved $1500 buckeroos, he should take me out to dinner next week to celebrate! Or, um, to console me in my um, sadness. That’s right. Because I’ll be all sad that we won’t have anything to save and therefore won’t have to pay out of pocket for freezing, storage and FETs that the insurance won’t cover… Yeah. Sad. That’s right.

(ooh! And Score! I totally bought a pile of HPTs. They should arrive on my doorstep tomorrow or the next day! They aren’t my beloved FRER’s, but I’m a girl on a budget now. And this should support my habit for at least a little while, right? Just, um, don’t tell my husband, okay? Oh for crying out loud, honey, they cost LESS THAN A DOLLAR EACH! And, no, I did not buy 300 of them. Just 297… KIDDING!)

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bored now.

very proud of myself for not having purchased any HPTs yet. Not that they’d show anything, but you’ve gotta have them ready, right?


Really, really, really done with this 2ww stuff.

Every one of my previous cycles I always had in my back pocket my exit strategy. So the 2ww never bothered me. I always knew that the cycle hadn’t worked (yes, I’m a negative nelly), so I was just twiddling my thumbs until the next CD3. I was completely surprised the two times it did work (and completely pissed off at the miscarriage the first time). But I always had the exit strategy: CD3, back to the clinic, start stims, keep going.

But I actually don’t exactly know what happens this time. PIO will keep CD3 from happening, so until I come off of it… no cycle start. And even if I do, what then? I don’t know if there was anything to freeze (I think not), so which is it, fresh or FET? Let’s assume fresh. If fresh, then what? I know you can’t move straight into another fresh cycle, but what does that mean? Does that mean straight to BCPs? Or does that mean waiting a month before BCPs? This is the missing piece of the puzzle piece for me. I think it means straight to BCPs. So 21 days of BCPs, Lupron on Day 19. Lupron Eval. on CD 2 or 3. Start Stims if it’s a go. I think. And I know SuperDoc said that this go around we’d be increasing my Follistim by 100IUs to start.

So is that the plan? I need a plan! I *always* have a plan, and right now, I’m a girl without a plan! This is not okay!

I *could* just make an appointment with SuperDoc to discuss said plan, but: 1. odds are good I won’t be able to get a consult appointment with him before my beta anyway, and 2. if I did, I’d feel ridiculous demanding a plan before I even get to a beta and then end up with a positive beta, as happened last time.

This is my fault. Normally I ask what my exit strategy is ahead of time – but I forgot that it’s all different now.

Now, see, I never used to be high maintenance. And then I went and had this super-high-risk, HOM pregnancy. And I *hated* to be a bother, but they put me on all this home-monitoring stuff and make me talk to a nurse three times a day and hauled me into the office twice a week and put me into the hospital a few times and, well… I learned how to be high maintenance, you see. And now?? I’m really good at it. So I blame the medical field for this. It’s all their fault.

Anyway, I’m not actually going to be high maintenance to them – I’m just going to be high maintenance here in my head. Oh wait, I’m typing all this out loud, aren’t I. Okay, fine. I’m going to be high maintenance publicly, to the blogosphere. But no one twisted your arm, put a gun to your head and forced you to read this blog. So, really? You asked for it!

Did I mention I’m bored?

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I swear, I am convinced that PIO makes my Allegra stop working. I cannot breathe, my eyes are all itchy, I’m sniffly, I’m stuffy, I’m teary-eyed, I’m sneezy, I’m ucky, I’m whiny (okay, that has nothing to do with Allegra except that when I feel this way, I get whiny). It’s like I have no allergy medicine on board. It’s as though the progesterone totally inactivates the Allegra. It’s completely ridiculous.

I cannot find appropriate google terms to bring my theory to life, but allergies can be aggravated during pregnancy – though this seems to be a phenomenon that is most severe in late pregnancy (29-36 weeks) so my bet is taking a few PIO shots is not the culprit. But, um. I still say the PIO is to blame. Because what else am I going to blame?

And I am getting too many darned migraines, which I know is the fault of the progesterone. And my screwed up body. Thanks for nothing.

And just think? If I get pregnant (hah!) I can stay on this stuff for EVER!

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